Young Plasma yFFP

Aging is an inevitable process that leads to a variety of health issues, including cognitive decline, muscle weakness, loss of mobility & flexibility, and chronic diseases. While there is no cure for aging, recent research suggests that a promising treatment called Young Plasma Exchange (yFFP®) may help mitigate some of the negative effects of aging.

Plasma is the light amber colored liquid that makes up about 55% of our blood volume. It is composed of water, salts, enzymes, growth factors, hormones, cytokines, and some of our body’s proteins including albumin and fibrinogen.

As we age and are exposed to toxins, our body can mount immune responses which contribute to inflammation. Chronic inflammation can damage healthy cells, tissues and organs which can lead to the development of disabling or life-threatening illnesses, such as Cancer, Type-2 diabetes, or Neurodegeneration and more.

Young fresh frozen plasma (yFFP®) is a process that involves removing young plasma from a young donor, ages 18- 25 years old. yFFP® Exchange is the process of taking the young plasma and infusing it into an older recipient. The goal is to introduce young, healthy plasma into the older recipient's bloodstream.

This yFFP® contains a variety of beneficial molecules, including growth factors, hormones, exosomes, and cytokines, which may help promote tissue regeneration, reduce inflammation, offset some of the negative effects of aging, helps reverse epigenetic aging, restore youthful vitality, reduce effects of autoimmune diseases, and improve overall health and wellness and promote longevity.

The young donor provides a sample of blood, which is then processed in a lab to remove the plasma. This plasma is then infused into the older recipient's bloodstream, which is typically done through an intravenous (IV) line. The entire process takes about 1-2 hours.

The rationale behind this treatment approach is that systemic factors present in young blood cross into the brain, where they counteract aging processes and neurodegeneration by modulating neuroinflammation, neurogenesis, and cognitive function. In essence, this approach attempts to rejuvenate the aging brain with infusions of plasma from young adults. Initial clinical trials grew, in part, out of parabiosis studies, in which old mice connected via their circulatory systems to young mice showed improvements on a wide range of outcome measures related to aging and neurodegeneration.

yFFP® Exchange Treatment

Texas is the only state in the United States and one of the only places in the world that you can experience this potentially life altering treatment. A growing number of clinics offer plasma from young donors for anti-aging. At Westchester Wellness Medicine, we encourage anyone considering these treatments to ask their health care providers to confirm that the FDA has reviewed the treatment that is investigational. At Westchester Wellness Medicine refer our clients to vetted clinics in Texas since they are a part of an investigational study on yFFP®.

Investigational young Fresh Frozen Plasma (yFFP®) Treatments Study YP042022. This study will employ epigenetic methylation and genomic testing and blood laboratory parameters to identify biologic age shifts and genome changes that might be attributable to the methods and frequency of administering at two dosage levels, approximately either 2 or 3 liters of yFFP® into study subjects within 30 days, for therapeutic uses across a wide spectrum of conditions. The study also measures changes in grip strength, balance, and cognitive function post infusion of yFFP®.

Benefits of Young Plasma Exchange yFFP®

Studies have shown that young plasma exchange may have several benefits, including:

Improved Cognitive Function
yFFP® may help improve cognitive function, such as memory, attention, and processing speed. Studies have shown that yFFP® can improve cognitive function in older adults with different forms of dementia and mild cognitive impairment. Some clients report almost immediate improvements in brain fog, inflammation, mental clarity, and focus.
Improved Physical Function
yFFP® may also improve physical function, such as muscle strength and endurance. Studies have shown that YPE can improve physical function in older adults with frailty and sarcopenia.
Reduced Inflammation
yFFP® may help reduce inflammation in the body, which is a common factor in many age-related diseases, such as heart disease and cancer.
Longer Lifespan/Reverse Epigenetic Age:
Animal studies have shown that yFFP® can increase lifespan and improve overall health in older animals. Current studies have shown up to 15-year epigenetic age reversal in patients that received a 2L plasma exchange with yFFP®.

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